R-125
Pure HFC (pentafluoroethane, CHF₂CF₃) — A1 non-flammable, GWP 3500. Rarely used as a standalone refrigerant; the dominant flammability-suppression component in HFC blends (R-410A, R-404A, R-407C, R-507A, others).
Lower toxicity (Occupational Exposure Limit ≥ 400 ppm). No flame propagation in air at standard atmospheric pressure and 60°C. R-134a, R-22, R-410A, R-404A, R-744 (CO2) are A1.
- Flammability
- None (no flame propagation)
- Toxicity
- Lower (OEL ≥ 400 ppm)
Classification per ANSI/ASHRAE Standard 34-2022. See full reference.
Saturation pressure-temperature curve
Saturation values from CoolProp 7.2.0 R125. Operating pressure on a running system differs — see the operating-pressure references for in-use values.
R-125 PT chart PDF — printable saturation table
Looking for the R-125 PT chart PDF for shop reference? The complete pressure-temperature saturation table is below — every 1° increment from −40°F to 150°F (or to the refrigerant's critical temperature). Use the Print / Save as PDF button in the table header to download a clean, table-only PDF (the rest of the page is hidden from the print output). Important service temperatures (normal boiling point, freezing point of water, residential AC evap and condenser targets) are tinted and tagged in the table for at-a-glance shop reference.
R-125 PT Chart — Pressure-Temperature Saturation Table
1° increments · Source: CoolProp 7.2.0 / manufacturer datasheet · hvacptcharts.com
| Temp (°F) | Pressure (PSIG) |
|---|---|
| -40°F | 6.8 |
| -39°F | 7.4 |
| -38°F | 7.9 |
| -37°F | 8.5 |
| -36°F | 9.1 |
| -35°F | 9.7 |
| -34°F | 10.3 |
| -33°F | 10.9 |
| -32°F | 11.5 |
| -31°F | 12.1 |
| -30°F | 12.8 |
| -29°F | 13.4 |
| -28°F | 14.1 |
| -27°F | 14.8 |
| -26°F | 15.5 |
| -25°F | 16.2 |
| -24°F | 16.9 |
| -23°F | 17.6 |
| -22°F | 18.4 |
| -21°F | 19.1 |
| -20°F | 19.9 |
| -19°F | 20.7 |
| -18°F | 21.5 |
| -17°F | 22.3 |
| -16°F | 23.1 |
| -15°F | 24.0 |
| -14°F | 24.8 |
| -13°F | 25.7 |
| -12°F | 26.6 |
| -11°F | 27.5 |
| -10°F | 28.4 |
| -9°F | 29.4 |
| -8°F | 30.3 |
| -7°F | 31.3 |
| -6°F | 32.2 |
| -5°F | 33.2 |
| -4°F | 34.2 |
| -3°F | 35.3 |
| -2°F | 36.3 |
| -1°F | 37.4 |
| 0°F | 38.4 |
| 1°F | 39.5 |
| 2°F | 40.6 |
| 3°F | 41.8 |
| 4°F | 42.9 |
| 5°F | 44.0 |
| 6°F | 45.2 |
| 7°F | 46.4 |
| 8°F | 47.6 |
| 9°F | 48.9 |
| 10°F | 50.1 |
| 11°F | 51.4 |
| 12°F | 52.7 |
| 13°F | 54.0 |
| 14°F | 55.3 |
| 15°F | 56.6 |
| 16°F | 58.0 |
| 17°F | 59.4 |
| 18°F | 60.8 |
| 19°F | 62.2 |
| 20°F | 63.6 |
| 21°F | 65.1 |
| 22°F | 66.6 |
| 23°F | 68.1 |
| 24°F | 69.6 |
| 25°F | 71.2 |
| 26°F | 72.7 |
| 27°F | 74.3 |
| 28°F | 75.9 |
| 29°F | 77.5 |
| 30°F | 79.2 |
| 31°F | 80.9 |
| 32°FH₂O freeze | 82.5 |
| 33°F | 84.3 |
| 34°F | 86.0 |
| 35°F | 87.8 |
| 36°F | 89.6 |
| 37°F | 91.4 |
| 38°F | 93.2 |
| 39°F | 95.1 |
| 40°F | 97.0 |
| 41°F | 98.8 |
| 42°F | 100.8 |
| 43°F | 102.7 |
| 44°F | 104.7 |
| 45°F | 106.7 |
| 46°F | 108.7 |
| 47°F | 110.8 |
| 48°F | 112.9 |
| 49°F | 115.0 |
| 50°F | 117.1 |
| 51°F | 119.3 |
| 52°F | 121.5 |
| 53°F | 123.7 |
| 54°F | 125.9 |
| 55°F | 128.2 |
| 56°F | 130.4 |
| 57°F | 132.8 |
| 58°F | 135.1 |
| 59°F | 137.5 |
| 60°F | 139.9 |
| 61°F | 142.3 |
| 62°F | 144.8 |
| 63°F | 147.2 |
| 64°F | 149.8 |
| 65°F | 152.3 |
| 66°F | 154.9 |
| 67°F | 157.5 |
| 68°F | 160.1 |
| 69°F | 162.8 |
| 70°F | 165.4 |
| 71°F | 168.2 |
| 72°F | 170.9 |
| 73°F | 173.7 |
| 74°F | 176.5 |
| 75°F | 179.4 |
| 76°F | 182.3 |
| 77°F | 185.2 |
| 78°F | 188.1 |
| 79°F | 191.1 |
| 80°F | 194.1 |
| 81°F | 197.1 |
| 82°F | 200.2 |
| 83°F | 203.3 |
| 84°F | 206.4 |
| 85°F | 209.6 |
| 86°F | 212.8 |
| 87°F | 216.0 |
| 88°F | 219.3 |
| 89°F | 222.6 |
| 90°F | 226.0 |
| 91°F | 229.3 |
| 92°F | 232.8 |
| 93°F | 236.2 |
| 94°F | 239.7 |
| 95°F | 243.2 |
| 96°F | 246.8 |
| 97°F | 250.4 |
| 98°F | 254.0 |
| 99°F | 257.7 |
| 100°F | 261.4 |
| 101°F | 265.1 |
| 102°F | 268.9 |
| 103°F | 272.8 |
| 104°F | 276.6 |
| 105°F | 280.5 |
| 106°F | 284.5 |
| 107°F | 288.4 |
| 108°F | 292.5 |
| 109°F | 296.5 |
| 110°F | 300.6 |
| 111°F | 304.8 |
| 112°F | 309.0 |
| 113°F | 313.2 |
| 114°F | 317.5 |
| 115°F | 321.8 |
| 116°F | 326.1 |
| 117°F | 330.6 |
| 118°F | 335.0 |
| 119°F | 339.5 |
| 120°F | 344.0 |
| 121°F | 348.6 |
| 122°F | 353.2 |
| 123°F | 357.9 |
| 124°F | 362.6 |
| 125°F | 367.4 |
| 126°F | 372.2 |
| 127°F | 377.1 |
| 128°F | 382.0 |
| 129°F | 387.0 |
| 130°F | 392.0 |
| 131°F | 397.1 |
| 132°F | 402.2 |
| 133°F | 407.4 |
| 134°F | 412.6 |
| 135°F | 417.9 |
| 136°F | 423.2 |
| 137°F | 428.6 |
| 138°F | 434.0 |
| 139°F | 439.5 |
| 140°F | 445.1 |
| 141°F | 450.8 |
| 142°F | 456.4 |
| 143°F | 462.2 |
| 144°F | 468.0 |
| 145°F | 473.9 |
| 146°F | 479.9 |
| 147°F | 485.9 |
| 148°F | 492.1 |
| 149°F | 498.3 |
| 150°F | 504.6 |
| Temp (°C) | Pressure (kPa) |
|---|---|
| -40°C | 47 |
| -39°C | 54 |
| -38°C | 61 |
| -37°C | 68 |
| -36°C | 76 |
| -35°C | 84 |
| -34°C | 92 |
| -33°C | 100 |
| -32°C | 109 |
| -31°C | 118 |
| -30°C | 127 |
| -29°C | 136 |
| -28°C | 146 |
| -27°C | 156 |
| -26°C | 167 |
| -25°C | 177 |
| -24°C | 188 |
| -23°C | 200 |
| -22°C | 211 |
| -21°C | 224 |
| -20°C | 236 |
| -19°C | 249 |
| -18°C | 262 |
| -17°C | 275 |
| -16°C | 289 |
| -15°C | 304 |
| -14°C | 318 |
| -13°C | 334 |
| -12°C | 349 |
| -11°C | 365 |
| -10°C | 381 |
| -9°C | 398 |
| -8°C | 415 |
| -7°C | 433 |
| -6°C | 451 |
| -5°C | 469 |
| -4°C | 488 |
| -3°C | 508 |
| -2°C | 528 |
| -1°C | 548 |
| 0°CH₂O freeze | 569 |
| 1°C | 591 |
| 2°C | 613 |
| 3°C | 635 |
| 4°C | 658 |
| 5°C | 682 |
| 6°C | 706 |
| 7°C | 730 |
| 8°C | 755 |
| 9°C | 781 |
| 10°C | 807 |
| 11°C | 834 |
| 12°C | 862 |
| 13°C | 890 |
| 14°C | 919 |
| 15°C | 948 |
| 16°C | 978 |
| 17°C | 1,008 |
| 18°C | 1,040 |
| 19°C | 1,071 |
| 20°C | 1,104 |
| 21°C | 1,137 |
| 22°C | 1,171 |
| 23°C | 1,205 |
| 24°C | 1,241 |
| 25°C | 1,277 |
| 26°C | 1,313 |
| 27°C | 1,351 |
| 28°C | 1,389 |
| 29°C | 1,428 |
| 30°C | 1,467 |
| 31°C | 1,508 |
| 32°C | 1,549 |
| 33°C | 1,591 |
| 34°C | 1,633 |
| 35°C | 1,677 |
| 36°C | 1,721 |
| 37°C | 1,766 |
| 38°C | 1,813 |
| 39°C | 1,859 |
| 40°C | 1,907 |
| 41°C | 1,956 |
| 42°C | 2,005 |
| 43°C | 2,056 |
| 44°C | 2,107 |
| 45°C | 2,159 |
| 46°C | 2,213 |
| 47°C | 2,267 |
| 48°C | 2,322 |
| 49°C | 2,378 |
| 50°C | 2,436 |
| 51°C | 2,494 |
| 52°C | 2,553 |
| 53°C | 2,613 |
| 54°C | 2,675 |
| 55°C | 2,738 |
| 56°C | 2,801 |
| 57°C | 2,866 |
| 58°C | 2,933 |
| 59°C | 3,000 |
| 60°C | 3,069 |
| 61°C | 3,139 |
| 62°C | 3,211 |
| 63°C | 3,284 |
| 64°C | 3,359 |
| 65°C | 3,436 |
Full saturation values at 1° increments — toggle between °F / PSIG and °C / kPa. Use Print / Save as PDF for laminated shop reference, or download the CSV / JSON below for use in other tools. R-125 PT chart data: CoolProp 7.2.0 (REFPROP-compatible Helmholtz EOS) or manufacturer datasheet, validated against AHRI Standard 700-2019.
At a glance
Chemistry
Lubricant compatibility
Rarely used standalone. Primary applications are as a blend component (R-404A, R-407C, R-410A, R-507A) and as a clean agent (FM-200/HFC-227ea-class fire suppression in some lists, though HFC-227ea is the more common agent).
Trade names
- Suva 125Chemours
- Genetron 125Honeywell
Common applications
- Blend component in R-404A, R-407C, R-410A, R-507A
- Fire suppression (some applications)
Properties
- Boiling point (1 atm)-48.1°C / -54.6°F
- Critical point150.8°F at 510 PSIG
- Molar mass120.02 g/mol
- Temperature glideNegligible (0.00°F)
- ODP0
- GWP (AR5, 100-yr)3500
- GWP (AR6, 100-yr)3740
- Atmospheric lifetime28.2 years
What is R-125?
R-125 is pentafluoroethane (CHF₂CF₃) — a pure HFC with A1 safety classification and very high GWP (3500) [ashrae34][ipccar5]. R-125 is rarely used as a standalone refrigerant because its very high GWP and unfavorable thermodynamic properties make better-balanced alternatives preferable for nearly all direct refrigeration applications.
R-125's dominant role is as a blend component. R-125 is the primary flammability-suppression ingredient in major HFC blends — its A1 classification and high vapor pressure make it effective at keeping multi-component HFC blends in the A1 non-flammable safety class. Major blends using R-125: R-410A (50% R-125), R-404A (44%), R-407C (25%), R-507A (50%), R-407A (40%), R-407F (30%), and many others.
Where R-125 is used
- Component in R-410A (50% mass) — primary residential AC HFC blend
- Component in R-404A (44%) — legacy commercial refrigeration
- Component in R-407C (25%) — R-22 retrofit blend
- Component in R-507A (50%) — alternative R-502 replacement
- Component in R-448A, R-449A — modern R-404A retrofit blends
- Standalone fire suppression in some specialty applications
Regulatory & phase-down status
R-125 as a standalone refrigerant faces phase-down pressure under EPA AIM Act and EU F-Gas Regulation due to its very high GWP (3500). However, R-125 is not typically used standalone, so the direct refrigerant-level restrictions matter less than the blend-level restrictions on R-410A, R-404A, etc. [aimact].
As HFC blends containing R-125 are phased down (R-410A in residential AC from 2025, R-404A in commercial refrigeration through 2024-2025), R-125 production volumes decrease accordingly. Modern low-GWP blends use less R-125 (R-454B contains zero R-125; R-454C contains zero R-125) — the structural trajectory is toward minimizing R-125 content in HFC formulations.
Service notes
R-125 is rarely encountered as a standalone refrigerant in field service. Service technicians work with R-125 as a component in HFC blends; the blend behavior dominates service considerations.
POE oil compatible. Standard HFC service procedures apply when encountered in blend form.
Operating cycle
Phase-down timeline
No phase-down milestones documented for R-125 in this build. This may mean: (a) no regulatory phase-down currently published; (b) the refrigerant has local regulatory schedules not yet transcribed into the site dataset; or (c) it is a specialty refrigerant outside the main regulatory frameworks. For authoritative current status, consult the EPA AIM Act allocations (40 CFR Part 84), EU F-Gas Regulation 517/2014 + 2024/573, and the relevant national implementations of the Kigali Amendment.
Global warming potential, in context
No peer-comparison group is defined for R-125. Its 100-year GWP per IPCC AR5 is 3500 — above the EPA AIM Act 700 GWP cap and well above the EU F-Gas 150 cap.
Peer-comparison groups are defined for refrigerants that compete in the same application sector (residential AC, commercial MT/LT, chillers, mobile AC). Specialty or research-grade refrigerants without a clear peer set don't appear in any group; their GWP is shown above in absolute terms instead.
Reading the R-125 PT chart
R-125's PT chart is a single saturation curve. The pressure envelope is high — R-125 at 70°F is approximately 235 PSIG (CoolProp 7.2.0). This high vapor pressure is part of what makes R-125 useful as a blend component for raising the overall blend pressure envelope (e.g., R-125's high pressure contributes to R-410A's high operating pressure profile).
R-125 is rarely encountered as a standalone refrigerant in field service, so its standalone PT chart is primarily a reference for understanding blend behavior.
HFC chemistry — five fluorines on a 2-carbon backbone
R-125 is pentafluoroethane: CHF₂CF₃ — five fluorines, one hydrogen, two carbons. The high fluorine content gives R-125 its non-flammability (A1) and its long atmospheric lifetime (~29 years) — fluorine bonds resist OH radical attack that breaks down most HFCs.
The long atmospheric lifetime is the chemistry feature driving R-125's very high GWP (3500). Each kilogram of R-125 released to atmosphere persists for decades and traps 3500× more heat over 100 years than 1 kg of CO₂.
GWP 3500 — among the highest of mainstream HFCs
R-125's GWP of 3500 places it among the highest of mainstream HFC refrigerants — alongside R-143a (4470) and R-23 (14800). The very high GWP is the structural reason HFC blends containing significant R-125 content have high overall GWP.
The 50% R-125 content in R-410A contributes most of R-410A's 2088 GWP. The 44% R-125 content in R-404A contributes substantially to R-404A's 3922 GWP. Reducing or eliminating R-125 is the primary mechanism for reducing GWP in modern low-GWP HFC blend formulations.
R-125 as the flammability-suppression component — and its trade-off
R-125's commercial value derives from its A1 non-flammability and ability to suppress flammability in HFC blends containing A2L components. R-32 (the high-capacity HFC component used in most modern blends) is A2L; R-125 added to R-32 in sufficient mass fraction suppresses flammability to produce A1 blends.
The trade-off: high GWP in exchange for A1 classification. Engineering teams have accepted this trade-off for decades, producing high-GWP A1 blends (R-410A, R-404A, R-407C) that became industry standards.
Modern policy reverses the trade-off. EU F-Gas Regulation and EPA AIM Act prioritize GWP reduction over safety classification preservation; new low-GWP blends accept A2L classification (R-454B, R-454C, R-455A) and eliminate or minimize R-125. The structural trajectory is away from R-125-heavy blends.
How to think about R-125 in 2026 and beyond
R-125's market role is shrinking as HFC blends containing significant R-125 content face phase-down pressure. R-410A (50% R-125) phase-down in residential AC from 2025; R-404A (44% R-125) phase-down in commercial refrigeration through 2024-2025. New low-GWP blends use less R-125 or none at all.
For service technicians, R-125 work is encountered as blend service — recovering and recharging R-410A, R-404A, R-407C, R-448A, R-449A and similar blends rather than handling standalone R-125. The blend behavior dominates service procedures.
For equipment specifiers, the trajectory away from R-125-heavy blends is the key trend. New equipment specifications increasingly use R-32 (no R-125), R-454B (no R-125), R-454C (no R-125), R-455A (no R-125) rather than legacy R-410A or R-404A formulations.
Frequently asked
›What is R-125 used for?
Almost entirely as a component in HFC blends. R-125's role is flammability suppression — its A1 classification and high vapor pressure suppress flammability in blends containing A2L components (like R-32) to produce A1 blends. Major blends: R-410A (50%), R-404A (44%), R-407C (25%), R-507A (50%) [ashrae34].
›What's R-125's GWP?
3500 per IPCC AR5 — very high [ipccar5]. The 29-year atmospheric lifetime drives the high GWP. R-125's high GWP is the primary reason blends containing significant R-125 content (R-410A 50%, R-404A 44%) have high overall GWP and face aggressive phase-down.
›Why is R-125 used if its GWP is so high?
Flammability suppression. R-125 is A1 (non-flammable) and is effective at suppressing flammability in HFC blends containing A2L components like R-32 (mildly flammable). Without R-125 (or equivalent A1 components), most HFC blends would be A2L and require A2L-rated equipment.
The trade-off — accepting high GWP for A1 classification — is the engineering tension driving the current HFC-to-A2L transition. Modern low-GWP blends (R-454B, R-454C, R-455A) accept A2L classification to avoid R-125's GWP burden.
›Can R-125 be used as a refrigerant by itself?
Technically yes (it has a usable PT curve), but rarely done in commercial practice. R-125 as a standalone refrigerant has very high GWP without compensating thermodynamic advantages over alternatives. Some specialty applications use R-125 as a fire-suppression agent (FE-25, FM-200 family).
›What lubricant does R-125 use?
POE oil typically when encountered in blend form [ahri700]. Standalone R-125 (rare) would use POE.
›Is R-125 being phased out?
Indirectly, through the phase-down of HFC blends containing R-125. As R-410A, R-404A, R-407C face EPA AIM Act and EU F-Gas restrictions, R-125 production volumes decrease. The newer low-GWP blends (R-454B, R-454C, R-455A) contain little or no R-125, reflecting the structural trajectory away from high-GWP blend components.
Sources & citations
- [1]ASHRAE Standard 34-2022
- [2]IPCC AR5 (2014) Working Group I, Chapter 8, Table 8.A.1
- [3]CoolProp 7.2.0
- [4]EPA AIM Act — 40 CFR Part 84 Subpart BFinal Rule Oct 2021https://www.epa.gov/climate-hfcs-reduction
- [5]AHRI Standard 700-2019
- [6]NIST Chemistry WebBook — Pentafluoroethane (CAS 354-33-6)
- [7]ASHRAE Handbook of Refrigeration 2022